Given the name of the Holy Cross in Spanish, its English name derives from the British vessel HMS Indefatigable. Located near the center of the Galapagos archipelago very close to Baltra airport, Santa Cruz is the center of the tourism and it hosts the largest human population in the archipelago at the town of Puerto Ayora.
This is the home port to many yachts, as well as the Charles Darwin Research Station and the headquarters of the Galápagos National Park Service are located here.